{"id":6,"date":"2022-09-24T18:39:22","date_gmt":"2022-09-24T18:39:22","guid":{"rendered":"https:\/\/surtovol.com\/?page_id=6"},"modified":"2022-10-04T10:18:41","modified_gmt":"2022-10-04T14:18:41","slug":"home","status":"publish","type":"page","link":"https:\/\/surtovol.com\/","title":{"rendered":"Home"},"content":{"rendered":"\t\t
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Getting to the Nucleus of the Matter.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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We use our non-viral s50 capsule technology platform and structural insights
to provide partners with innovative and disruptive solutions
for next-generation gene therapy delivery.\u00a0<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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We use our non-viral s50 capsule technology platform and structural insights to provide partners with innovative and disruptive solutions for next-generation gene therapy delivery.\u00a0<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Our Story<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Surtovol\u2122 is a pioneer in
ligand-directed nanocapsule delivery of gene therapy at the biologically-relevant sub-50 nanometer (\u201cs50\u201d) threshold.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Our Focus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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We prioritize partnering in
next-generation gene therapy that restores protein and cell function — applications that are ideally-suited for s50 capsule\u2019s non-inflammatory, non-immunogenic and large-payload profile.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Our Platform<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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At\u00a0~\u00a0<\/b><\/span><\/span>20 nm diameter, s50 capsules are 1\/3<\/span>rd<\/sup><\/span> size of liposomes, and co-opt size-sensitive lipid raft uptake into target cells.<\/span>(1)
<\/sup><\/span>s50\u2019s are also uniquely modular — RNA\/DNA\/pDNA cargo up to 17 kb, + any hydrophilic ligand (e.g., 1MM Da hyaluronan), can be used.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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(1)<\/sup><\/span>\u00a0 <\/span>https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4126856\/<\/span><\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Reaching the nucleus
on the path less traveled.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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s50 technology is a novel strategy for partners to overcome gene therapy\u2019s #1 rate-limiting step — i.e., avoiding endolysosomal capture after entering the cell.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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A.\u00a0 <\/span>Employing biologically-relevant protein matrix chamber slides, s50 capsules co-opt the size-sensitive lipid raft pathway of cells and deliver the majority of their oligo cargo (shown here = 63%<\/b>) to the\u00a0<\/span>nucleus.<\/span><\/p>

B.\u00a0 <\/span>By comparison, liposomes deliver a fractional share of their oligo cargo (shown here = 9%<\/b>) to the nucleus.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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s50 in vivo<\/i>: Overcoming a series of delivery barriers to effect a gene therapy cure. <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The benefit of nucleus access is of course dependent upon the delivery vehicle\u2019s ability to also overcome in vivo\u2019s <\/i>other delivery barriers.<\/span><\/p>

In this 50-week study<\/span>(2) <\/sup><\/span>of hemophilia A mice treated IV with s50 capsules bearing a collaborator\u2019s 12.8 kb pDNA, liver sinusoidal endothelial cells were targeted using 1MM Da hyaluronan ligands. No immune-suppression steps were used in this study.<\/span><\/p>

Findings showed treatment resulted in an effective cure of hemophilia A in the subject mice, without any observed adverse effects.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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(2)\u00a0 <\/sup><\/span>https:\/\/www.jci.org\/articles\/view\/34332<\/span><\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Leverage our proprietary, non-viral s50 capsule platform to create next-generation gene therapies that restore protein and cell function, including self-amplifying RNA, small activating RNA, and plasmid DNA.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\ns50\u2019s \u201cplug and play\u201d modularity provides partners with flexibility vis-\u00e0-vis payload, ligand, and route-of-administration to evaluate and develop next-generation gene therapy targets and drugs.\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tLet's Connect<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Getting to the Nucleus of the Matter. We use our non-viral s50 capsule technology platform and structural insightsto provide partners with innovative and disruptive solutionsfor next-generation gene therapy delivery.\u00a0 We use our non-viral s50 capsule technology platform and structural insights to provide partners with innovative and disruptive solutions for next-generation gene therapy delivery.\u00a0 Our Story […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/surtovol.com\/index.php\/wp-json\/wp\/v2\/pages\/6","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/surtovol.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/surtovol.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/surtovol.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/surtovol.com\/index.php\/wp-json\/wp\/v2\/comments?post=6"}],"version-history":[{"count":769,"href":"https:\/\/surtovol.com\/index.php\/wp-json\/wp\/v2\/pages\/6\/revisions"}],"predecessor-version":[{"id":974,"href":"https:\/\/surtovol.com\/index.php\/wp-json\/wp\/v2\/pages\/6\/revisions\/974"}],"wp:attachment":[{"href":"https:\/\/surtovol.com\/index.php\/wp-json\/wp\/v2\/media?parent=6"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}